Predictive Role for Serum Aldo-Keto Reductase Family1 Member B10 for Early Detection of Hepatocellular Carcinoma in Egyptian Patients

Background: Most patients with hepatocellular carcinoma (HCC) are diagnosed at late stages despite of improvement screening programs and lack effective diagnostic methods for cases preclinical HCC leads to a low rate early detection. Aldo-keto reductase family 1 member B10 (AKR1B10) is associated several types cancer. However, our knowledge, the significance AKR1B10 measurement in stage has poorly understood.
 Aim
 To evaluate performance serum hepatitis C virus (HCV)-related liver disorders its unique role diagnosing HCC.
 Methods
 Serum was detected by sandwich ELISA 30 HCV-related HCC, HCV related cirrhosis, 20 healthy controls. Both α-fetoprotein (AFP) levels were analyzed, evaluated compared.
 Results
 significantly elevated compared with. The sensitivity (86.7.0%) specificity (70%) diagnosis high cutoff value 0.945 ng/ml, while alpha fetoprotein had 67% 88% detection among studied groups point higher than 17.9. ng/ml. Furthermore, concurrent Alpha increased 97.6% 100% ≥150 AFP negative predictive diagnosis.
 Conclusions
 we concluded current study that as biomarker early-stage HCC. Compared alone, combination an